RapamycinFungusV1, Main, Exploration, bibRecord, 001949

Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR.

Identifieur interne : 001949 ( Main/Exploration ); précédent : 001948; suivant : 001950

Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR.

Auteurs : Chi Kwan Tsang [États-Unis] ; Paula G. Bertram ; Wandong Ai ; Ryan Drenan ; X F Steven Zheng

Source :

The EMBO journal [ 0261-4189 ] ; 2003.

RBID : pubmed:14609951

Descripteurs français

KwdFr :
- ADN ribosomique (MeSH), Antifongiques (pharmacologie), Chromatine (effets des médicaments et des substances chimiques), Chromatine (métabolisme), Hybridation fluorescente in situ (MeSH), Levures (effets des médicaments et des substances chimiques), Levures (métabolisme), Nucléole (effets des médicaments et des substances chimiques), Nucléole (métabolisme), Phosphatidylinositol 3-kinases (métabolisme), Phosphotransferases (Alcohol Group Acceptor) (métabolisme), Protéines de Saccharomyces cerevisiae (métabolisme), RNA polymerase I (métabolisme), Sirolimus (pharmacologie).
MESH :
- effets des médicaments et des substances chimiques : Chromatine, Levures, Nucléole.
- métabolisme : Chromatine, Levures, Nucléole, Phosphatidylinositol 3-kinases, Phosphotransferases (Alcohol Group Acceptor), Protéines de Saccharomyces cerevisiae, RNA polymerase I.
- pharmacologie : Antifongiques, Sirolimus.
- ADN ribosomique, Hybridation fluorescente in situ.

English descriptors

KwdEn :
- Antifungal Agents (pharmacology), Cell Nucleolus (drug effects), Cell Nucleolus (metabolism), Chromatin (drug effects), Chromatin (metabolism), DNA, Ribosomal (MeSH), In Situ Hybridization, Fluorescence (MeSH), Phosphatidylinositol 3-Kinases (metabolism), Phosphotransferases (Alcohol Group Acceptor) (metabolism), RNA Polymerase I (metabolism), Saccharomyces cerevisiae Proteins (metabolism), Sirolimus (pharmacology), Yeasts (drug effects), Yeasts (metabolism).
MESH :
- chemical , drug effects : Chromatin.
- chemical , metabolism : Chromatin, Phosphatidylinositol 3-Kinases, Phosphotransferases (Alcohol Group Acceptor), RNA Polymerase I, Saccharomyces cerevisiae Proteins.
- chemical , pharmacology : Antifungal Agents, Sirolimus.
- drug effects : Cell Nucleolus, Yeasts.
- metabolism : Cell Nucleolus, Yeasts.
- chemical : DNA, Ribosomal, In Situ Hybridization, Fluorescence.

Abstract

The target of rapamycin (TOR) protein is a conserved regulator of ribosome biogenesis, an important process for cell growth and proliferation. However, how TOR is involved remains poorly understood. In this study, we find that rapamycin and nutrient starvation, conditions inhibiting TOR, lead to significant nucleolar size reduction in both yeast and mammalian cells. In yeast, this morphological change is accompanied by release of RNA polymerase I (Pol I) from the nucleolus and inhibition of ribosomal DNA (rDNA) transcription. We also present evidence that TOR regulates association of Rpd3-Sin3 histone deacetylase (HDAC) with rDNA chromatin, leading to site-specific deacetylation of histone H4. Moreover, histone H4 hypoacetylation mutations cause nucleolar size reduction and Pol I delocalization, while rpd3Delta and histone H4 hyperacetylation mutations block the nucleolar changes as a result of TOR inhibition. Taken together, our results suggest a chromatin-mediated mechanism by which TOR modulates nucleolar structure, RNA Pol I localization and rRNA gene expression in response to nutrient availability.

DOI: 10.1093/emboj/cdg578
PubMed: 14609951
PubMed Central: PMC275436

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Main, to step Curation: 001908

Le document en format XML

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<term>Chromatin (metabolism)</term>
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<term>In Situ Hybridization, Fluorescence (MeSH)</term>
<term>Phosphatidylinositol 3-Kinases (metabolism)</term>
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<front><div type="abstract" xml:lang="en">The target of rapamycin (TOR) protein is a conserved regulator of ribosome biogenesis, an important process for cell growth and proliferation. However, how TOR is involved remains poorly understood. In this study, we find that rapamycin and nutrient starvation, conditions inhibiting TOR, lead to significant nucleolar size reduction in both yeast and mammalian cells. In yeast, this morphological change is accompanied by release of RNA polymerase I (Pol I) from the nucleolus and inhibition of ribosomal DNA (rDNA) transcription. We also present evidence that TOR regulates association of Rpd3-Sin3 histone deacetylase (HDAC) with rDNA chromatin, leading to site-specific deacetylation of histone H4. Moreover, histone H4 hypoacetylation mutations cause nucleolar size reduction and Pol I delocalization, while rpd3Delta and histone H4 hyperacetylation mutations block the nucleolar changes as a result of TOR inhibition. Taken together, our results suggest a chromatin-mediated mechanism by which TOR modulates nucleolar structure, RNA Pol I localization and rRNA gene expression in response to nutrient availability.</div>
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<Abstract><AbstractText>The target of rapamycin (TOR) protein is a conserved regulator of ribosome biogenesis, an important process for cell growth and proliferation. However, how TOR is involved remains poorly understood. In this study, we find that rapamycin and nutrient starvation, conditions inhibiting TOR, lead to significant nucleolar size reduction in both yeast and mammalian cells. In yeast, this morphological change is accompanied by release of RNA polymerase I (Pol I) from the nucleolus and inhibition of ribosomal DNA (rDNA) transcription. We also present evidence that TOR regulates association of Rpd3-Sin3 histone deacetylase (HDAC) with rDNA chromatin, leading to site-specific deacetylation of histone H4. Moreover, histone H4 hypoacetylation mutations cause nucleolar size reduction and Pol I delocalization, while rpd3Delta and histone H4 hyperacetylation mutations block the nucleolar changes as a result of TOR inhibition. Taken together, our results suggest a chromatin-mediated mechanism by which TOR modulates nucleolar structure, RNA Pol I localization and rRNA gene expression in response to nutrient availability.</AbstractText>
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	Serveur d'exploration sur la rapamycine et les champignons
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Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR.

Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR.

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